HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → HCID 86755451, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoxazole, 4-(chloromethyl)-3,5-dimethyl- | HCID 88246 | — |
| Reactant | 4-(3-Acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride | HCID 135671180 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Product | HCID 86755451 | HCID 86755451 | 112.6% |
Reaction Steps
Using an analogouls procedure to that described for the starting material in Example 1, 4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (400 mg) was reacted in the presence of potassium iodide (16 mg) with 4-chloromethyl-3,5-dimethylisoxazole (177 mg) to give 4-(3-acetoxy)-4-methylanilino)-7-(3,5-dimethylisoxazol-4-ylmethoxy)-6-methoxyquinazoline (342 mg, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071921 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-c637926b6f2d4054892e84a30398f411 |
| Source note | uspto-grants-2000_06 |