7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride → 7-Benzyloxy-6-methoxy-4-phenoxyquinazoline

HRID 1420909노트

반응식

HRID 1420909 반응식
Cl.[CH2:2]([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14](Cl)=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O>[CH2:2]([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([O:9][C:10]3[CH:19]=[CH:18][CH:13]=[CH:12][CH:11]=3)=[N:15][CH:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

3

반응물 1

HCID 220308367-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride

생성물 1

HCID 218748147-Benzyloxy-6-methoxy-4-phenoxyquinazoline수율 190%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
110 °C

실험 절차

7-Benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (1.6 g, 4.7 mmol), (prepared as described for the starting material in Example 1), was then added and the reaction mixture heated at 110° C. for 2 hours. The mixture was allowed to cool, water was added and the mixture extracted with ethyl acetate (3×100 ml). The combined extracts were then washed with 2M sodium hydroxide solution, water and brine. Removal of the solvent under reduced pressure gave 7-benzyloxy-6-methoxy4-phenoxyquinazoline (1.6 g, 95%) as a yellowish solid.

후처리

  1. additionwas then added
  2. temperatureto cool
  3. extractionthe mixture extracted with ethyl acetate (3×100 ml)
  4. washThe combined extracts were then washed with 2M sodium hydroxide solution, water and brine
  5. customRemoval of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-824e8bd0e64c434f8c740244446a6f5f
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071921

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