HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Benzyloxy-6-methoxy-4-phenoxyquinazoline → 7-Hydroxy-6-methoxy-4-phenoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Benzyloxy-6-methoxy-4-phenoxyquinazoline | HCID 21874814 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 7-Hydroxy-6-methoxy-4-phenoxyquinazoline | HCID 135496137 | 89% |
Reaction Steps
7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (160 mg, 0.44 mmol) in TFA (3 ml) was heated at reflux for 30 minutes. The solvent was removed by evaporation and the residue treated with aqueous sodium hydrogen carbonate solution. The precipitated product was collected by filtration, washed with water and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (105 mg, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071921 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-e7d3678249304c1eb71c13f1c6f916bf |
| Source note | uspto-grants-2000_06 |