HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Benzyloxy-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline → 4-(4-Chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Benzyloxy-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline | HCID 21874825 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 4-(4-Chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline | HCID 135616204 | 90.7% |
Reaction Steps
A solution of 7-benzyloxy-4-(4-chloro-2-fluorophenoxy)-6-methoxyquinazoline (451 mg, 1.1 mmol) in TFA (4.5 ml) was heated at reflux for 3 hours. The mixture was diluted with toluene and the volatiles removed by evaporation. The residue was triturated with methylene chloride, collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline (320 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071921 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-efd2288b67224c16b806dcbdcbc7480e |
| Source note | uspto-grants-2000_06 |