HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(N-methyl-N-(4-pyridyl)amino)propanol → 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-(N-methyl-N-(4-pyridyl)amino)propoxy)quinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(N-methyl-N-(4-pyridyl)amino)propanol | HCID 22625038 | — |
| Reactant | 4-(4-Chloro-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline | HCID 135513720 | — |
| Product | 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-(N-methyl-N-(4-pyridyl)amino)propoxy)quinazoline hydrochloride | HCID 22624912 | 119% |
Reaction Steps
Using a procedure analogous to that described in Example 47, 3-(N-methyl-N-(4-pyridyl)amino)propanol (116 mg, 0.7 mmol) was treated with 4-(4-chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinazoline (160 mg, 0.5 mmol), (prepared as described for the starting material in Example 24), to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(3-(N-methyl-N-(4-pyridyl)amino)propoxy)quinazoline hydrochloride (150 mg, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071921 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-ec852234ee4e476ebdcea9be30cea6fe |
| Source note | uspto-grants-2000_06 |