HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-(Tetrahydropyran-2-yloxy)ethoxy)pyridine → 2-(Pyridin-3-yloxy)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-(Tetrahydropyran-2-yloxy)ethoxy)pyridine | HCID 22624891 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(Pyridin-3-yloxy)ethan-1-ol | HCID 21908997 | 86% |
Reaction Steps
A solution of 3-(2-(tetrahydropyran-2-yloxy)ethoxy)pyridine (1.54 g, 7 mmol) in acetic acid (8 ml), THF (4 ml) and water (2 ml) was heated at 50° C. for 4 hours. The volatiles were removed by evaporation and the residue azeotroped with toluene to give 3-(2-hydroxyethoxy)pyridine (820 mg, 86%) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071921 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-e7f70f11f9c9458ab6d57b489c6c0d5d |
| Source note | uspto-grants-2000_06 |