HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 77927-91-4
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Methyl-1-[4-(methylthio)phenyl]-1-propanone | HCID 852539 | — |
| Reactant | 2-Hydroxy-2-methyl-1-(4-(methylsulfonyl)phenyl)propan-1-one | HCID 15428514 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 77927-91-4 | HCID 12648842 | — |
Reaction Steps
To a solution of the alcohol of Step 3 (2.87 g, 11.8 mmol) and the acid from step 1 (2.0 g, 15.4 mmol) in CH2Cl2 (30 mL) was added CMC (7.5 g, 17.7 mmol), along with 50 mg of DMAP. After stirring overnight, H2O (20 mL) was ad ded and the product was extracted with CH2Cl2. The organic layer was dried (MgSO4), filtered and evaporated. Purification was effected by flash chromatography (1:5 EtOAc:hexane) to yield 2.97 g of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071954 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-1f709676e2ee4e65a31ffe2bfc487f7a |
| Source note | uspto-grants-2000_06 |