Triethylamine → HCID 53649700, compound

Participants

Reaction Steps

To the alcohol of Example 8 Step 3 (800 mg, 2.25 mmol) in CH2Cl2 (10 mL) at -20∞C. were added Et3N (943 mL, 6.05 mmol) and MsCl (348 mL, 4.51 mmol). After a period of 1 h at 0∞C., saturated NaHCO3 was added. The organic phase was separated, dried over Na2SO4, filtered and evaporated. To the crude mesylate in THF (10.0 mL) was added a 1M THF solution of tetrabutylammonium fluoride (6.77 mL, 6.77 mmol). After a period of 2 h at 50∞C., the reaction mixture was partitioned between 25% NH4OAc and EtOAc. The organic phase was separated, dried over Na2SO4, filtered and evaporated. The title compound (370 mg) was purified by flash chromatography.

Provenance & Evidence