(Diethylamino)sulfur trifluoride → HCID 15542192, compound

Participants

Reaction Steps

To the alcohol of Example 12 Step 2 (300 mg, 0.882 mmol) in CH2Cl2 (10 mL) at 0∞C. was added DAST (142 mL, 1.05 mmol). After a period of 18 h at room temperature and 2 days at reflux, the reaction mixture was partitioned between 25% aqueous NH4OAc and EtOAc. The organic phase was separated, dried over Na2SO4, filtered and evaporated under reduced pressure. The title compound (48 mg) was purified by flash chromatography.

Provenance & Evidence