Triethylamine → 1,4-Dioxaspiro(4.5)decan-8-yl methanesulfonate

Participants

Reaction Steps

To an ice cold solution of the alcohol from Step 1 (4.59 g, 29 mmol) and triethylamine (8.0 mL, 57 mmol) in dichloromethane (100 mL) was added methanesulfonyl chloride (3.3 mL, 43 mmol). The reaction was then diluted with water (80 mL) and extracted with CH2Cl2 (2×50 mL). The combined organic layers were dried over MgSO4 and concentrated to give the title compound as a yellow oil.

Provenance & Evidence