Diiodomethane → HCID 15542197, compound

Participants

Reaction Steps

To a solution of Et2Zn (0.82 mL) in 50 mL of ClCH2CH2Cl cooled at 0∞C. was added 1.3 mL of CH2I2 slowly. The mixture was stirred for 5 min. and treated with 0.63 g of the olefin of example 18 at 0∞C. The mixture was stirred for 20 min. at 0∞C. and 3 h at room temperature. The reaction was quenched by addition of 50 mL of saturated NH4Cl solution and the product was extracted with EtOAc (200 mL) The extract was dried over MgSO4, filtered and concentrated. The crude product was purified by flash chromotography eluted with 3:2 hexane/EtOAc to give 400 mg of the title product as a white solid.

Provenance & Evidence