HuagongsheHuagongshe Chemistry Print Report · For research reference only
Avermectin → Ivermectin CRS
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Avermectin | HCID 6858006 | — |
| Reactant | Tris-(octylphenyl)-phosphine | HCID 22561076 | — |
| Product | Ivermectin CRS | HCID 9812710 | — |
Reaction Steps
4.3 g of avermectin (B1a and B1b mixture) are, after addition of 53.2 mg of tris-(octylphenyl)-phosphine, hydrogenated using the conditions given in Example 1 (B). After a hydrogenation time of 7 hours, a crude ivermectin product is obtained which, according to HPLC analysis, contains 1.3% of avermectin, 94.8% of ivermectin and 2% of tetrahydroavermectin.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06072052 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-ec79b6c038e94f30b0a3c8bf2cfedba0 |
| Source note | uspto-grants-2000_06 |