反应详情

820 mg of Lawesson's reagent was added to a solution of 330 mg of 3,4-bis(3-indolyl)-1H-pyrrole-2,5-dione in 50 ml of dimethoxyethane and the mixture was heated to reflux for 1 hour. 410 mg of Lawesson's reagent were then added and the mixture was heated to reflux for a further 1 hour. The solvent was evaporated and the residue was purified on silica gel with ethyl acetate/hexane (1:4). Recrystallization from diethyl ether/hexane gave 30 mg of 5-thioxo-3,4-bis(3-indolyl)-3-pyrrolin-2-one, m.p. 254°-257° C.

1. temperaturethe mixture was heated
2. temperatureto reflux for 1 hour
3. temperaturethe mixture was heated
4. temperatureto reflux for a further 1 hour
5. customThe solvent was evaporated
6. customthe residue was purified on silica gel with ethyl acetate/hexane (1:4)
7. customRecrystallization from diethyl ether/hexane