Thiourea → HCID 86745174, compound

Participants

Reaction Steps

50 mg of thiourea were added to a solution, heated at reflux, of 150 mg of the product of Example 68 in 15 ml of ethanol. The mixture was heated for 1 hour and the solvent was then evaporated. The residue was chromatographed on silica gel with 20% methanol in dichloromethane to give 10 mg of 3-[1-[3-(amidinothio)propyl]-3-indolyl]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione methanesulphonate, m.p. 164°-165° C.

Provenance & Evidence