HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(1-methyl-3-indolyl)-4-(4-pyridyl)-1H-pyrrole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-(1-Methyl-3-indolyl)-4-(4-pyridyl)furan-2,5-dione | HCID 18780247 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(1-methyl-3-indolyl)-4-(4-pyridyl)-1H-pyrrole-2,5-dione | HCID 18780274 | — |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
200 mg of 3-(1-methyl-3-indolyl)-4-(4-pyridyl)furan-2,5-dione were treated with 5 ml of DMF and 5 ml of 33% aqueous ammonia. The resulting solution was heated at 140° C. for 17 hours. After cooling, the suspension was diluted with water. The product was filtered off, washed with water and dried to give 144 mg of 3-(1-methyl-3-indolyl)-4-(4-pyridyl)-1H-pyrrole-2,5-dione, m.p. 332°-334° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE036736 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-bc7bf9e421254f168562f45ce5fd372f |
| Source note | uspto-grants-2000_06 |