反应详情

温度

50 °C

450 mg of the product of Example 58 in 20 ml of DMSO were treated with 116 mg of sodium cyanide. The mixture was heated at 50° C. for 8 hours, then cooled and poured into water. The mixture was extracted with ethyl acetate and the extracts were dried. Concentration and chromatography on silica gel with toluene/ acetic acid (9:1) gave a solid which was triturated with diethyl ether, filtered off and dried. There were obtained 69 mg of 3-[1-(3-cyanopropyl)-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione, m.p. 245°-247° C.

1. temperaturecooled
2. extractionThe mixture was extracted with ethyl acetate
3. customthe extracts were dried
4. concentrationConcentration and chromatography on silica gel with toluene/ acetic acid (9:1)
5. customgave a solid which
6. customwas triturated with diethyl ether
7. filtrationfiltered off
8. customdried