Dimethyl Sulfoxide → HCID 18780292, compound

HRID 1421191Notes

Reaction equation

HRID 1421191 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:34])[NH:13][C:14](=[O:33])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][CH2:26]COS(C)(=O)=O)[CH:17]=2)=[CH:3]1.C[S-].[Na+].[CH3:38][S:39]([CH3:41])=O>O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:34])[NH:13][C:14](=[O:33])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][CH2:26][CH2:38][S:39][CH3:41])[CH:17]=2)=[CH:3]1

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 4378561Sodium methanethiolateHCID 151630513-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione

Product 1

HCID 18780292HCID 18780292, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

100 mg of the product of Example 58 in 5 ml of DMSO were treated with 30 mg of sodium methanethiolate. The solution was stirred for 30 minutes and then diluted with water. The precipitate was filtered off, washed with water and dried to give 52 mg of 3-(1-methyl-3-indolyl)-4-[1-[3-(methylthio)propyl]-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 222°-224° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-82dd8e2414eb42e3ba887733d07c2d9f
Source dataset
uspto-grants-2000_06
Patent number
USRE036736

Reaction notes

Loading…