Iodine → HCID 21969095, compound

Participants

Reaction Steps

To a solution of 2'-O-acetyl-3'-deoxyuridine (2.47 g) in acetonitrile (150 ml), diammonium cerium (IV) nitrate (2.51 g) and iodine (1.39 g) were added and allowed to react at 80° C. for one hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, the obtained residue w s extracted with ethyl acetate, and the extract was washed with 5% aqueous solution of sodium bisulfite and saturated brine. The ethyl acetate layer was dried with anhydrous magnesium sulfate, and the solvent was evaporated to afford 2'-O-acetyl-3'-deoxy-5'-iodouridine (3.37 g, yield: 93.1%).

Provenance & Evidence