Potassium sodium tartarate → HCID 70296498, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1,1 g (3.0 mmoles) of 1-(2,4-dimethoxystyryl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine in 15 ml of anhydrous tetrahydrofurane is cooled to a temperature between 0° C. and 5° C., and 0.114 g (3.0 mmoles) of lithium aluminium hydride is added to it. The reaction mixture is stirred at 25° C. for 2 hours, cooled again to a temperature between 0° C. and 5° C. and decomposed with 0.36 ml of 10% aqueous potassium sodium tartrate solution. Then it is stirred further for 1 hour at 25° C., the precipitate is filtered off, the filtrate is dried and evaporated under reduced pressure. The crude end-product is recrystallized from 10 ml of ethanol, filtered, washed three times with 1 ml each of ethanol and dried at a temperature between 80° C. and 100° C. Thus 0.84 g (76.0%) of the desired product is obtained.

Provenance & Evidence