Dimethylamine → HCID 15838105, compound

HRID 1421219Notes

Reaction equation

HRID 1421219 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]1[C:12](=[O:23])[N:13]([CH2:19][CH2:20][O:21][CH3:22])[CH2:14][CH:15]([C:16](O)=[O:17])[C:5]2=1.[CH3:24][NH:25][CH3:26]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]1[C:12](=[O:23])[N:13]([CH2:19][CH2:20][O:21][CH3:22])[CH2:14][CH:15]([C:16]([N:25]([CH3:26])[CH3:24])=[O:17])[C:5]2=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 18780530HCID 18780530, compound

Product 1

HCID 15838105HCID 15838105, compound

Procedure

The preparation is carried out as in Example 1.5, from 8.3 g (26 mmol) of (±)-6-chloro-2-(2-methoxyethyl)-9-methyl-1-oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-4-carboxylic acid and from dimethylamine. 8.6 g of product are isolated, which product is recrystallized from propan-2-ol. 6.9 g (19 mmol) of product are obtained.

Sources & evidence

ORD record
ord-27878b106aa445198fe4482ee9cc0866
Source dataset
uspto-grants-2000_06
Patent number
US06075021

Reaction notes

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