反应详情

温度

50 °C

Glacial acetic acid (4.5 ml 75 mmol) was added to a suspension of 6-amino-1-methyluracil (5.66 g, 50 mmol) in hot water (100 ml). Sodium nitrite (4.14 g) was added in portions and the reaction mixture was stirred for 1 hour. The resulting solid was collected by filtration, washed with water (75 ml) and resuspended in water (100 ml). After warming to 50° C., sodium dithionite (10 g) was added in portions maintaining the reaction temperature between 50° C. and 55° C. After stirring at 50° C. for an additional 1 hour, the mixture was cooled to room temperature and filtered. The solid was washed with water (2×25 ml), with acetone (2×25 ml) and then dried under vacuum. Yield=5.6 g.

1. filtrationThe resulting solid was collected by filtration
2. washwashed with water (75 ml)
3. additionsodium dithionite (10 g) was added in portions
4. temperaturemaintaining the reaction temperature between 50° C. and 55° C
5. stirringAfter stirring at 50° C. for an additional 1 hour
6. temperaturethe mixture was cooled to room temperature
7. filtrationfiltered
8. washThe solid was washed with water (2×25 ml), with acetone (2×25 ml)
9. customdried under vacuum