反应详情

A solution of 1-methyl-5,6-diaminouracil (2.5 g) in acetic anhydride (25 ml) was heated at reflux for 2 hours and then concentrated. The residue was dissolved in 10% sodium hydroxide solution (50 ml) and heated at reflux for 2 hours. After cooling to room temperature the solution was acidified to pH 4 with concentrated hydrochloric acid. The product was filtered, washed with water (15 ml), with acetone (15 ml) and then dried under vacuum. Yield 1.8 g.

1. temperatureat reflux for 2 hours
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in 10% sodium hydroxide solution (50 ml)
4. temperatureheated
5. temperatureat reflux for 2 hours
6. filtrationThe product was filtered
7. washwashed with water (15 ml), with acetone (15 ml)
8. customdried under vacuum