Water → HCID 18780696, compound

Participants

Reaction Steps

1-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl-1,3-dihydro-2H-benzimidazol-2-one (0.416 g, 1.36 mmol) was added to a suspension of 60% sodium hydride (0.06 g, 1.49 mmol, dispersion in oil) in N-methylpyrrolidinone (3 ml) and stirred for 2 hours. More N-methylpyrrolidinone (2 ml) was added followed by 1-bromo-2-chloroethane (0.203 ml, 0.351 g, 2.44 mmol). The resultant mixture was allowed to stir at room temperature for 16 h then water was added and the mixture extracted with ethyl acetate (2×30 ml). The organic layer was washed with water (4×50 ml), brine (50 ml), dried (MgSO4).filtered and evaporated in vacuo to give a light brown oil.

Provenance & Evidence