反应详情

N-Ethylaniline (3.0 g, 25 mmol) was dissolved in 80 ml of toluene and about 30 ml of the solvent was distilled off in order to obtain a dry solution. To this boiling solution was added 1,2-dihydro-4hydroxy-5-methoxy-1-methyl-2-oxo-quinoline-3-carboxylic acid ethyl ester (2.7 g, 10 mmol). The ethanol formed during the reaction was distilled off together with some toluene for about 4 hours. The reaction mixture was cooled to room temperature. The precipitate was collected, washed with cold toluene and hexane and dried to give the title compound (2.8 g), yield 80%.

1. distillationabout 30 ml of the solvent was distilled off in order
2. customto obtain a dry solution
3. distillationwas distilled off together with some toluene for about 4 hours
4. customThe precipitate was collected
5. washwashed with cold toluene and hexane
6. customdried