Tert-Butyl nitrite → HCID 9951338, compound

Participants

Reaction Conditions

Reaction Steps

To 5-amino-3-cyano-4-(cyclopent-2-enyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazole (300 mg, 0.77 mmol, Example 7) in dry tetrahydrofuran (THF) (8 ml ) heated at 65° C. was added dropwise tert-butyl nitrite (239 mg, 2.3 mmol) in dry THF (2 ml) over 30 min. The solution was heated for a further 3 hr at 65-70° C. The solvent was removed in vacuo and the resulting brown oil was purified by silica chromatography (eluting with DCM) to yield 170 mg of the title compound as a white solid.

Provenance & Evidence