HCID 9821579, compound → HCID 9821695, compound

HRID 1421504Notes

Reaction equation

HRID 1421504 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[CH:21]1[CH2:25][CH2:24][CH:23]=[CH:22]1>C(O)C.[Pd]>[NH2:1][C:2]1[N:6]([C:7]2[C:8]([Cl:18])=[CH:9][C:10]([C:14]([F:15])([F:17])[F:16])=[CH:11][C:12]=2[Cl:13])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[CH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 1

HCID 9821579HCID 9821579, compound

Product 1

HCID 9821695HCID 9821695, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

5-Amino-3-cyano-4-(cyclopent-2-enyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (200 mg, 0.5 mmol, Example 7) in ethanol (10 ml) was hydrogenated at room temperature and 345 kPa (50 p.s.i.) over 10% palladium on charcoal for 9 h. The catalyst was removed by filtration, washed with ethanol and the combined filtrates concentrated in vacuo to yield an oil.

Workup

  1. customwas hydrogenated at room temperature
  2. customThe catalyst was removed by filtration
  3. washwashed with ethanol
  4. concentrationthe combined filtrates concentrated in vacuo
  5. customto yield an oil

Sources & evidence

ORD record
ord-844a681863b34a62afebf7a5c3fca2c0
Source dataset
uspto-grants-2000_06
Patent number
US06077859

Reaction notes

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