反应详情

温度

55 °C

3-(4-Methoxyphenylsulfonyl)propenoic acid (200 mgs), excess furan (5.0 ml), and dry toluene (5.0 ml) were combined and warmed to 55° C. (at which time starting material went into solution) for overnight. The cooled reaction was concentrated in vacuo to a tan solid which was a mixture of starting material and product. The material was taken up in toluene (5 ml) and furan (10 ml) and heated to 69° C. overnight. The cooled reaction mixture was concentrated in vacuo to give 251 mgs of crude 3-(4-Methoxyphenylsulfonyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid as a dark tan solid.

1. customThe cooled reaction
2. concentrationwas concentrated in vacuo to a tan solid which
3. additiona mixture of starting material and product
4. temperaturefuran (10 ml) and heated to 69° C. overnight
5. customThe cooled reaction mixture
6. concentrationwas concentrated in vacuo