反应详情

Into a toluene suspension (200 ml) of aluminum chloride (26 g), a toluene solution (50 ml) of p-fluorobenzoyl chloride (16 g) was dropwise added at a room temperature. Subsequently, the mixture was stirred for 20 hours at a room temperature, and then carefully poured into ice-water. Toluene (200 ml) was added thereto, and then the organic layer was separated, and washed successively with aqueous 2N hydrochloric acid solution, water and aqueous saturated sodium chloride solution, followed by drying over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 4-fluoro-4'-methylbenzophenone (16 g).

1. customthe organic layer was separated
2. washwashed successively with aqueous 2N hydrochloric acid solution, water and aqueous saturated sodium chloride solution
3. dry with materialby drying over anhydrous sodium sulfate
4. distillationThe solvent was distilled off under reduced pressure