2-Chlorophenol → HCID 21883500, compound

Participants

Reaction Steps

The title compound was prepared from 2-chlorophenol and ethyl 6-chloro-7-fluoro-2-(trifluoromethyl)-2H-1-benzopyran-3-carboxylate (Example 183, Step 2) via a procedure similar to that described in Example 183, Steps 3 and 4: mp 199.0-199.1° C. 1H NMR (acetone-d/300 MHz) 7.94 (s, 1H), 7.76 (s, 1H), 7.65 (m, 1H), 1.51 (m, 1H), 7.38 (m, 1H), 7.32 (m, 1H), 6.44 (s, 1H), 5.85 (q, 1H, J=7.0 Hz). 13F NMR (acetone-d6 /28; MHz) -79.5 (d, J=6.5 Hz). ESHRMS m/z 402.9752 (M-H, Calc'd 402.9751). Anal. Calc'd for C17H9Cl2F3O4 : C, 50.40; H, 2.24; Cl, 17.50. Found: C, 50.42; H, 2.12; Cl, 17.72.

Provenance & Evidence