Sulfuric Acid → HCID 18780172, compound

Participants

Reaction Steps

One gram (1.0 g) of 2-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-ethoxycarbonyl-4-methyl-5-trifluoromethylpyridazin-3-one and 1.0 g of sulfuric acid are mixed at room temperature, and stirred for 30 minutes. The reaction mixture was poured into water and extracted with 100 ml of ethyl acetate. The organic layer was washed with 50 ml of water 3 times and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure and the obtained crystals was washed with 50 ml of n-hexane to afford 0.78 g of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-6-ethoxycarbonyl-4-methyl-5-trifluoromethylpyridazin-3-one, the present compound 1-27 (yield 87%).

Provenance & Evidence