Sulfuric Acid → HCID 18780170, compound

Participants

Reaction Conditions

Reaction Steps

Twenty mililiters (20 ml) of a mixture of sulfuric acid and water (v/v=1/1), and 7.3 g of 2-(4-chloro-3-isopropoxycarbonylphenyl)-6-ethoxycarbonyl-4-methyl-5-trifluoromethylpyridazin-3-one (the present compound 1-109) were mixed and heated for 7 hours on a 150° C. oil bath. The reaction solution was cooled to room temperature, poured into 100 ml of water. The precipitated crystals were filtered off, washed with 50 ml of water 3 times, dissolved with 200 ml of ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to afford 4.88 g of 2-(4-chloro-5-carboxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one (yield:89%).

Provenance & Evidence