Hydrochloric Acid → HCID 69926998, compound

Participants

Reaction Steps

Treatment of the free base (303.6 mg) in EtOH-Et2O (30 ml; 1:2) with 1.0M HCl in Et2O (0.62 ml) as described for the compound of Example 7 followed by the recrystallisation (THF-Et2O) afforded the title compound as an off-white amorphous solid (highly hygroscopic). δH (CD3OD) 1.50-1.90 (8H, br m), 2.11 (3H, s), 3.67 (2H, d, J 8.3 Hz), 3.76 (3H, s), 4.40 (1H, t, J 8.3 Hz), 4.73 (1H, br m), 6.79 (1H, s), 6.83 (1H, s), 6.84 (1H, s), 6.85-6.95 (4H, m), 7.28 (2H, d, (fine split), J 8.5 Hz), 7.50 (2H, dd, J 6.9, 2.3 Hz), 7.80 (2H, d, J 6.4 Hz), and 8.60 (2H, d, J 5.9 Hz).

Provenance & Evidence