HCID 15428582, compound → HCID 9863977, compound

Participants

Reaction Steps

4-(-2-Oxo-2-H-pyridin-1-yl)benzyl bromide from Step 3 (1.7 mmol, 450 mg ) and 4-(1-trityl-1H-imidazol-4-ylmethyl)benzonitrile (1.7 mmol) were suspended in CH3CN and heated to reflux for 3 hours. The reaction mixture was concentrated and the residue taken up in MeOH and refluxed for 2 hours. The MeOH was removed in-vacuo. The resulting oil was partitioned between EtOAc and saturated NaHCO3. The aqueous layer was extracted twice with EtOAc. The organic layers were combined, washed with brine, dried (MgSO4), filtered and concentrated to yield an oil which was purified by flash chromatography using 5% IPA/CHCl3 saturated with NH3 as an eluent. Pure fractions were collected and concentrated to give a white solid. The solids were washed with warm 50% EtOAc/Hexane and collected on a frit. The white solid was collected and dried under high vacuum at 50° for 12 hours to give the title compound.

Provenance & Evidence