Water → HCID 18779697, compound

Participants

Reaction Conditions

Reaction Steps

To N-bromosuccinimide (0.166 g, 0.929 mmol) in CH2Cl2 (3 mL) at 0° C. was added dimethylsulfide (0.082 mL, 1.11 mmol). The resulting suspension was cooled to -20° C. and a solution of the alcohol from Step 1 (0.146 g, 0.62 mmol) in CH2Cl2 was added dropwise over 2 minutes. The reaction mixture was stirred at 0° C. for 6 hrs and then poured into water and extracted with CH2Cl2. The extracts were dried (Na2SO4) and evaporated in vacuo. The residue was chromatographed (silica gel, EtOAc: CH2Cl2 1:1 as eluent) to afford the title compound as a white solid.

Provenance & Evidence