2-Pyridone → HCID 18779708, compound

Participants

Reaction Steps

2-Pyridinone (1.00 g, 10.5 mmol), 2-bromo-5-methylpyridine (1.81 g, 10.5 mmol), Copper (0.013 g, 0.20 mmol) and K2CO3 (1.60 g, 11.6 mmol) were heated at 180° C. for 16 hrs. The brown reaction mixture was cooled, diluted with EtOAc and washed with saturated NaHCO3. The aqueous layer was extracted with EtOAc (2×) and the combined organic extracts were washed with brine, dried (Na2SO4) and evaporated in vacuo. The residue was chromatographed (silica gel, EtOAc as eluent) to afford the title compound as a white solid.

Provenance & Evidence