Potassium Carbonate → HCID 70295664, compound

Participants

Reaction Steps

1-Aminooxysulfonyl-2,4,6-trimethylbenzene (0.5 g, 0.002 mole) was added all at once to a stirred solution of 3-[4-chloro-6-fluoro-3-phenyl-1,2(2H)-benzisoxazol-7-yl]-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione (0.8 g, 0.002 mole) and potassium carbonate (0.4 g, 0.003 mole) in THF (50 mL). Upon completion of addition, the reaction mixture was stirred at ambient temperature for about 18 hours. After this time, the reaction mixture was filtered and the filtrate was concentrated to a residue. The residue was subjected to silica gel column chromatography using 4:1 hexane and ethyl acetate. The product-containing fractions were combined and concentrated, yielding 0.6 gram of Compound 34, m.p. 171-173° C. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence