Acetone → HCID 18706828, compound

Participants

Reaction Steps

To the amino alcohol compound D (1.27 g, 0.01 mol) were added 2-amino-4,6-dichloropyrimidine (1.64 g, 0.01 mol), ethanol (40 ml) and triethylamine (2.1 ml), and the mixture was refluxed for one day. The solvent was distilled away under reduced pressure. Ethyl acetate was added to the residue and the mixture was subjected to hot filtration. The solvent of the filtrate was distilled away under reduced pressure and the residue was isolated by silica gel column chromatography (chloroform:methanol=50:1) to give colorless prism crystals (0.86 g, 33.8%) of the objective compound (compound No. 50), m.p. 201-203° C. (acetone).

Provenance & Evidence