Triethylamine → HCID 88258910, compound

Participants

Reaction Steps

Methanesulfonyl chloride (0.04 ml, 0.5 mmol) was added to a stirred solution of trans-7-hydroxy-4-(4-(4-phenylbenzoylamino)butyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline(E3, 200 mg, 0.4 mmol) and triethylamine (0.07 ml, 0.5 mmol) in dichloromethane (5 ml) at room temperature. The mixture was stirred for 12 h and then poured onto saturated aqueous K2CO3 (10 ml) and extracted onto dichloromethane (3×10 ml). The combined extracts were washed with brine, dried (Na2SO4) and evaporated in vacuo to give an off-white solid. Chromatography on silica using 50-100% ethyl acetate /pentane as elution gradient, afforded the free base of the title compound (200 mg, 94%). The free base was treated with 1M ethereal HCl in dichloromethane to afford after evaporation the title compound as a colourless solid.

Provenance & Evidence