Triethylsilane → HCID 178428085, compound

Participants

Reaction Steps

To a solution of the title compound of 1E (0.101 g, 0.108 mmol) in CH2Cl2 (1 ml) was added NH4F (0.010 g, 0.43 mmol) and triethylsilane (0.069 ml, 0.43 mmol) followed by addition of 2 ml TFA. The reaction mixture was stiired at ambient temperature for 12 h. It was partitioned between CH2Cl2 and saturated sodium bicarbonate (NaHCO3) solution. The CH2Cl2 layer was dried over MgSO4, filtered, and concentrated under vacuum to give the crude product. The crude product was chromatographed on silica gel with CH3OH--CHCl3 --NH4OH (6:94:0.1) as eluents to afford the title compound of example 1, 10 mg (0.019 mmol, 19% yield for two steps).

Provenance & Evidence