4-(Bromoacetyl)benzonitrile → HCID 18707469, compound

Participants

Reaction Steps

Using the same procedure as described in example 1D, the title compound of 3C (0.355 g, 0.78 mmol) and 4-cyanophenacyl bromide (193 mg, 0.86 mmol) in the presence of potassium bis(trimethylsilyl)-amide (193 mg, 0.86 mmol) reacted to yield 0.232 g (0.39 mmol, 50% yield) of the title compound of example 3D after chromatographic purification. Cl-Ms: m/z 598.3 [M+1].

Provenance & Evidence