Trifluoroacetic acid → HCID 18707477, compound

Participants

Reaction Steps

The above fluoromethylphosphonic acid di-tert-butyl ester (1.29 g, 2-7 mmol) was dissolved in dichloromethane (10 ml) and trifluoroacetic acid (2.5 ml) was added and the mixture was stirred at room temperature for 16 h. The mixture was filtered and the filtrate was evaporated in vacuo. The residue was partitioned between ethyl acetate (100 ml) and water (50 ml) and a solid was formed in the aqueous phase. This was filtered off and dried in vacuo at 50° C. affording 55 mg (6%) of the title compound as a solid,

Provenance & Evidence