HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dimethoxyphenyl)-1,3-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloroacetone | HCID 10793 | — |
| Reactant | 3,4-Dimethoxythiobenzamide | HCID 2758490 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(Chloromethyl)-2-(3,4-dimethoxyphenyl)-1,3-thiazole | HCID 2079396 | 59.1% |
Reaction Steps
1.5 g of 1,3-dichloroacetone and 2.3 g of 3,4-dimethoxythiobenzamide were suspended in 100 ml of ethanol. The suspension was heated for 3 hours to complete the reaction. The solvent was removed by distillation. The residue was purified by silica gel column chromatography to obtain 1.86 g of 2-(3,4-dimethoxyphenyl)-4-chloromethylthiazole as a colorless viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06080764 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-5498671472d94442b51712a9af07884e |
| Source note | uspto-grants-2000_06 |