HCID 18707311, compound → HCID 18707291, compound

HRID 1421990Notes

Reaction equation

HRID 1421990 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]2[S:14][CH:15]=[C:16]([C:18]3[CH:23]=[C:22]([CH:24]=[O:25])[C:21]([OH:26])=[C:20]([C:27]([O:29][CH3:30])=[O:28])[CH:19]=3)[N:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2].B.[Na]>CO>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]2[S:14][CH:15]=[C:16]([C:18]3[CH:23]=[C:22]([CH2:24][OH:25])[C:21]([OH:26])=[C:20]([C:27]([O:29][CH3:30])=[O:28])[CH:19]=3)[N:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2]

Participants

4

Reactant 2

HCID 18707311HCID 18707311, compoundHCID 178418435HCID 178418435, compound2×

Product 1

HCID 18707291HCID 18707291, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was suspended 300 mg of 2-(3,4-diethoxyphenyl)-4-(3-methoxycarbonyl-4-hydroxy-5-formylphenyl)thiazole with stirring. Thereto was added 26.5 mg of sodium boron hydride at 0° C. The mixture was stirred at room temperature for 1 hour. 26.5 mg of sodium boron hydride was further added, and the resulting mixture was stirred at the same temperature for 1 hour. The solvent was removed from the reaction mixture by distillation. To the residue were added 30 ml of dichloromethane and 15 ml of water, and phase separation was conducted. The organic layer was washed with 10 ml of a saturated aqueous sodium chloride solution, dried and subjected to distillation to remove the solvent to obtain 300 mg of 2-(3,4-diethoxyphenyl)-4-(3-methoxycarbonyl-4-hydroxy-5-hydroxymethylphenyl)thiazole.

Workup

  1. stirringThe mixture was stirred at room temperature for 1 hour
  2. stirringthe resulting mixture was stirred at the same temperature for 1 hour
  3. customThe solvent was removed from the reaction mixture by distillation
  4. additionTo the residue were added
  5. custom30 ml of dichloromethane and 15 ml of water, and phase separation
  6. washThe organic layer was washed with 10 ml of a saturated aqueous sodium chloride solution
  7. customdried
  8. distillationsubjected to distillation
  9. customto remove the solvent

Sources & evidence

ORD record
ord-68f85bd303e74c5799f052ff1c4d3af8
Source dataset
uspto-grants-2000_06
Patent number
US06080764

Reaction notes

Loading…