3,4-Diethoxybenzene-1-carbothioamide → 2-(3,4-Diethoxyphenyl)-4-(5-carboxy-2-thiazolyl)thiazole

HRID 1422003Notes

Reaction equation

HRID 1422003 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11](=O)[CH2:12]Br)=[N:8][CH:7]=1)=[O:5])C.[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH3:29])[C:21]([NH2:23])=[S:22])[CH3:16]>>[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([C:21]2[S:22][CH:12]=[C:11]([C:9]3[S:10][C:6]([C:4]([OH:3])=[O:5])=[CH:7][N:8]=3)[N:23]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH3:29])[CH3:16]

Participants

3

Reactant 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 18707391HCID 18707391, compound

Product 1

HCID 187073432-(3,4-Diethoxyphenyl)-4-(5-carboxy-2-thiazolyl)thiazole

Procedure

5-Ethoxycarbonyl-2-(α-bromoacetyl)thiazole and 3,4-diethoxythiobenzamide were subjected to the same reaction as in Example 1 and then to the same hydrolysis as in Example 147 to obtain 2-(3,4-diethoxyphenyl)-4-(5-carboxy-2-thiazolyl)thiazole. monoleate in this order. To the solution was added the distilled water for injection to obtain a desired final volume. The resulting solution was filtered through an appropriate filter paper and sterilized. 1 ml of the thus prepared solution was filled into each ampul to prepare an injection.

Workup

  1. customto the same hydrolysis as in Example 147

Sources & evidence

ORD record
ord-12126ae55bbe46af9ce56eb289209400
Source dataset
uspto-grants-2000_06
Patent number
US06080764

Reaction notes

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