2-Bromo-5-nitrothiazole → HCID 178526846, compound

Participants

Reaction Steps

The title compound was prepared in the manner described in Example 108. Substituting 4-chlorobenzoyl chloride for the benzoyl chloride in Example 108 gave 4-chlorobenzoyl thiosemicarbazide and then 3-(4-chlorophenyl)-1,2,4-triazole-5-thione. Reaction of 2.34 g of the sodium salt of 3-(4-chlorophenyl)-1,2,4-triazole-5-thione with 2.09 g of 2-bromo-5-nitrothiazole as in Example 108 yielded 1.5 g of 3-(4-chlorophenyl)-5-[(5-nitrothiazol-2-yl)mercapto]-1,2,4-triazole as tan crystals, MP 181-184° C. 6.112. Example 112

Provenance & Evidence