2-Bromo-5-nitrothiazole → HCID 178434161, compound

Participants

Reaction Steps

Alternatively, 2-[(5-nitrothiazol-2-yl)mercapto]-5-methyl-1,3,4-thiadiazole is prepared by the general method of J Bourdais, P Dauvillier, P Gayral, M-C Rigothie, P Timon-David et al, 1981. Eur. J. Chem. Chim. Ther. 16: 233-240. 2-Bromo-5-nitrothiazole (2.09 g) and 1.32 g of 2-mercapto-5-methyl-1,3,4-thiadiazole in 10 mL of ethanol and 10 mL of 1 N potassium hydroxide are stirred at room temperature overnight. The precipitated solid is collected by vacuum filtration, washed with water and crystallized from ethyl acetate/hexane to give 1 g of the title compound as an off-white solid.

Provenance & Evidence