Benzoic acid, 4-hydroxy-3-nitro-, methyl ester → Methyl 3-amino-4-hydroxybenzoate

Participants

Reaction Steps

To a solution of the objective compound (11.4 g, 57.8 mmol) of Step (1) in ethyl acetate (300 mL) was added under nitrogen atmosphere 10% palladium carbon (1.80 g) and the mixture was stirred at room temperature for 18 hours under hydrogen atmosphere. The catalyst was filtered off and washed with ethyl acetate. The filtrate was concentrated under reduced pressure. The obtained solid was washed with ether-hexane (1:1) and dried in vacuo to give methyl 3-amino-4-hydroxybenzoate as a pale-brown solid (9.34 g, 97%).

Provenance & Evidence