Bromomethyl 4-methoxyphenyl ketone → HCID 11108777, compound

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Reaction Steps

4-Methoxy-2-n-propylpyridine was reacted with 4-methoxyphenacylbromide by the general synthetic principle outlined in example 23, step 5, to afford 1-ethyl-7-methoxy-2-(4-methoxyphenyl)indolizine in 86% yield. M.p. 101-103° C. 1H-NMR (DMSO-d6, 200 MHz) δ: 1.10 (t, 3H); 2.77 (q, 2H); 3.77 (s, 3H); 3.80 (s, 3H); 6.23 (dd, 1H); 6.65 (d, 1H); 7.00 (d, 2H); 7.35 (s, 1H); 7.38 (d, 2H); 8.06 (d, 1H). Analysis: Calculated for C18H19N1O2 : C, 76.84; H, 6.81; N, 4.98%. Found: C, 76.73; H, 6.94; N, 4.80%.

Provenance & Evidence