Sodium Bicarbonate → HCID 18707005, compound

Participants

Reaction Steps

3-Benzyloxy-2-propylpyridine was reacted with 4-benzyloxyphenacylbromide and with sodium hydrogen carbonate by the general synthetic principles outlined in example 1, step 2, to afford 1-ethyl-8-benzyloxy-2-(4-benzyloxyphenyl)indolizine as yellow crystals in 66% yield. M.p. 104-105° C. MS(SP): m/z 433 (M+). 1H--NMR (DMSO-d6, 200 MHz) δ: 1.10 (t, 3 H); 2.86 (q, 2 H); 5.12 (s, 2 H); 5.19 (s, 2 H); 6.13 (d, 1 H); 6.38 (t, 1 H); 7.06 (d, 2 H); 7.28-7.54 (m, 13 H); 7.77 (d, 1 H).

Provenance & Evidence