Ethyl 2-n-propylpyridine-3-carboxylate → Hydroxymethyl-2-n-propylpyridin

Participants

Reaction Steps

Ethyl 2-n-propylpyridine-3-carboxylate was reduced with lithium aluminum hydride by the general synthetic principle outlined in example 1, step 4, to afford 3 hydroxymethyl-2-n-propylpyridin as a yellow oil in 90% yield. 1H--NMR (CDCl3, 200 MHz) δ: 0.98 (t, 3 H); 1.72 (sextet, 2 H); 2.75 (t, 2 H); 3.35 (br s, 1 H); 4.74 (s, 2 H); 7.12 (dd, 1 H); 7.74 (dd, 1 H); 8.39 (dd, 1 H).

Provenance & Evidence